The next decade holds the promise of being the most exciting and productive in the history of research on disabilities. If we capitalize on the advances in research on genetics, neuroscience, and behavior over the past 30 years, we will be able to integrate these advances into a biobehavioral approach that will allow us to eradicate or prevent many of the disabilities that have puzzled our ancestors for centuries. Technology already exists to prevent most of them. Research now has to develop them, perfect them, make them cost-effective and ethically acceptable to the public. The role of the Prince Salman Center for Disability Research is to ensure that the Kingdom of Saudi Arabia and the Middle East take a lead role in making this revolution happen for its people with disabilities and their families. Best practices must be based on a strong validated research foundation. The Prince Salman Center has been organized to provide this function for the Kingdom. A substantial beginning has been made, but much remains to be done before The Prince Salman Center takes its rightful place in the international community of scholars dedicated to improving the quality of life for our brothers and sisters with disabilities.